Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice
Identifieur interne : 004362 ( Main/Exploration ); précédent : 004361; suivant : 004363Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice
Auteurs : Alistair J. Barber ; Peter H. Yu ; Alan A. BoultonSource :
- Life Sciences [ 0024-3205 ] ; 1993.
Abstract
In order to measure the chronic effects of monoamine oxidase-B (MAO-B) inhibitors on the physical and cognitive condition of 60 aged male mice, l-deprenyl or N-methyl-N-(2-pentyl)-propargylamine (M-2-PP) were administered in drinking water (10 μg/ml/day) for 37 weeks. The spontaneous open-field locomotion, balancing ability and weight gain of the mice were assessed continuously. At the end of the study the spatial learning ability of all surviving mice was assessed in a Morris water maze. Both drug groups exhibited a reduction in spontaneous locomotion at the same rate as the control group, while there were no changes in balancing ability. The mice receiving l-deprenyl, however, performed the water maze task less well than the control group. The mice receiving l-deprenyl also gained weight at a significantly reduced rate compared to both the M-2-PP and water treated groups. A brain MAO assay indicated that MAO-B was completely inhibited by both drugs while MAO-A remained unchanged. The implications of these data on longevity studies using l-deprenyl and other MAO-B inhibitors are discussed.
Url:
DOI: 10.1016/0024-3205(93)90251-W
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002065
- to stream Istex, to step Curation: 002065
- to stream Istex, to step Checkpoint: 001C59
- to stream Main, to step Merge: 004B65
- to stream Main, to step Curation: 004362
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice</title>
<author><name sortKey="Barber, Alistair J" sort="Barber, Alistair J" uniqKey="Barber A" first="Alistair J." last="Barber">Alistair J. Barber</name>
</author>
<author><name sortKey="Yu, Peter H" sort="Yu, Peter H" uniqKey="Yu P" first="Peter H." last="Yu">Peter H. Yu</name>
</author>
<author><name sortKey="Boulton, Alan A" sort="Boulton, Alan A" uniqKey="Boulton A" first="Alan A." last="Boulton">Alan A. Boulton</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C5C10CEC6AD4360B60174D21F2C41005814FCC04</idno>
<date when="1993" year="1993">1993</date>
<idno type="doi">10.1016/0024-3205(93)90251-W</idno>
<idno type="url">https://api-v5.istex.fr/document/C5C10CEC6AD4360B60174D21F2C41005814FCC04/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002065</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002065</idno>
<idno type="wicri:Area/Istex/Curation">002065</idno>
<idno type="wicri:Area/Istex/Checkpoint">001C59</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001C59</idno>
<idno type="wicri:doubleKey">0024-3205:1993:Barber A:chronic:effects:of</idno>
<idno type="wicri:Area/Main/Merge">004B65</idno>
<idno type="wicri:Area/Main/Curation">004362</idno>
<idno type="wicri:Area/Main/Exploration">004362</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice</title>
<author><name sortKey="Barber, Alistair J" sort="Barber, Alistair J" uniqKey="Barber A" first="Alistair J." last="Barber">Alistair J. Barber</name>
<affiliation><wicri:noCountry code="subField">0W0</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yu, Peter H" sort="Yu, Peter H" uniqKey="Yu P" first="Peter H." last="Yu">Peter H. Yu</name>
<affiliation><wicri:noCountry code="subField">0W0</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Boulton, Alan A" sort="Boulton, Alan A" uniqKey="Boulton A" first="Alan A." last="Boulton">Alan A. Boulton</name>
<affiliation><wicri:noCountry code="subField">0W0</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Life Sciences</title>
<title level="j" type="abbrev">LFS</title>
<idno type="ISSN">0024-3205</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1993">1993</date>
<biblScope unit="volume">53</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="739">739</biblScope>
<biblScope unit="page" to="747">747</biblScope>
</imprint>
<idno type="ISSN">0024-3205</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0024-3205</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In order to measure the chronic effects of monoamine oxidase-B (MAO-B) inhibitors on the physical and cognitive condition of 60 aged male mice, l-deprenyl or N-methyl-N-(2-pentyl)-propargylamine (M-2-PP) were administered in drinking water (10 μg/ml/day) for 37 weeks. The spontaneous open-field locomotion, balancing ability and weight gain of the mice were assessed continuously. At the end of the study the spatial learning ability of all surviving mice was assessed in a Morris water maze. Both drug groups exhibited a reduction in spontaneous locomotion at the same rate as the control group, while there were no changes in balancing ability. The mice receiving l-deprenyl, however, performed the water maze task less well than the control group. The mice receiving l-deprenyl also gained weight at a significantly reduced rate compared to both the M-2-PP and water treated groups. A brain MAO assay indicated that MAO-B was completely inhibited by both drugs while MAO-A remained unchanged. The implications of these data on longevity studies using l-deprenyl and other MAO-B inhibitors are discussed.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Barber, Alistair J" sort="Barber, Alistair J" uniqKey="Barber A" first="Alistair J." last="Barber">Alistair J. Barber</name>
<name sortKey="Boulton, Alan A" sort="Boulton, Alan A" uniqKey="Boulton A" first="Alan A." last="Boulton">Alan A. Boulton</name>
<name sortKey="Yu, Peter H" sort="Yu, Peter H" uniqKey="Yu P" first="Peter H." last="Yu">Peter H. Yu</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004362 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004362 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:C5C10CEC6AD4360B60174D21F2C41005814FCC04 |texte= Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice }}
This area was generated with Dilib version V0.6.29. |